Technology

Cell Alignment Strategies for Organ-on-Chip Technologies

Cell Culture / By /

The functionalities of organs and tissues are tightly linked with their structure and, the organisation of constituent cells. Cues from the surrounding extracellular matrix direct the orientation and alignment of cells with respect to one another through contact guidance [1]. This microenvironment is crucial in dictating cell fate; affecting morphology, proliferation, differentiation, response to stimuli, …

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Human on a Chip Focus: Vasculature Systems on a Chip

Organ-on-chips, Review / By /

The vasculature is the main structure of the circulatory system through which nutrients, oxygen and biological secretions are transported throughout the body. This large network has specific structures regarding their functions. Among all the vital ones, our vasculature carries blood from the largest arteries towards the tiniest capillaries. The functional disorders of the vascular system …

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Human on a Chip Focus: Digestive System on a Chip

Organ-on-chips / By /

The human digestive system is a powerful machine able to transform organic matter into energy, all while filtering out any threatening and unnecessary elements. This system is however not infallible; malfunctions can occur and pathogens can sometimes get past the screening process. To investigate these events and find a treatment or cure, researchers and pharmaceutical …

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Four Methods of 3D Cell Culture in Microfluidic Devices

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Recently, microfluidics and 3D cell culture technologies have merged, to increase the potential of in vitro modeling, in order to get even closer to Nature. The successful control of the cellular environment thanks to microfluidics in a 3D cell culture environment allows the study at the single-cell scale with mechanical control of cell shape, physicochemical …

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From Organ-on-Chips to Body-on-a-Chip

Organ-on-chips / By /

With the help of microfluidics, cell culture is taking the next steps with Organ-on-Chips technology. To highlight these incredible milestones, here we discuss a recent Nature review by Tagle et al.[i], members of the National Center for advancing Translational Sciences; We focus on the benefits of the field, discuss its challenges, and explain how Eden Tech can …

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The Advantages of Cell Culture Devices & Flexdym for Low-Cost Fabrication

Cell Culture / By /

Established Methods of Cell Culture Cell culture is a set of biological techniques used to grow cells outside their original in vivo environment, for the purpose of scientific experimentation. It is widely used for in vitro testing in biomedical science to study animal models. However, a great challenge in cell culture techniques is the mimicking …

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