Article

Cell Alignment Strategies for Organ-on-Chip Technologies The functionalities of organs and tissues are tightly linked with their structure and, the organisation of constituent cells. Cues from the surrounding extracellular matrix direct the orientation and alignment of cells with respect to one another through contact guidance [1]. This microenvironment is crucial in dictating cell fate; affecting […]

Polymers for Microfluidic Devices: Surface Functionalization Modern Point-of-Care diagnostic devices rely on microfluidic technology to analyze the smallest amount of fluid, for the highest measurement precision possible. To do so, the microfluidic devices require powerful tools to detect and measure targeted elements (e.g., pathogens). This can be achieved by coating the microfluidic channel walls with

Digestive System On a Chip The vasculature is the main structure of the circulatory system through which nutrients, oxygen and biological secretions are transported throughout the body. This large network has specific structures regarding their functions. Among all the vital ones, our vasculature carries blood from the largest arteries towards the tiniest capillaries. The functional

Human on a Chip Focus: Digestive System on a Chip The human digestive system is a powerful machine able to transform organic matter into energy, all while filtering out any threatening and unnecessary elements. This system is however not infallible; malfunctions can occur and pathogens can sometimes get past the screening process. To investigate these

3D Cell culture & Microfluidics Recently, microfluidics and 3D cell culture technologies have merged, to increase the potential of in vitro modeling, in order to get even closer to Nature. The successful control of the cellular environment thanks to microfluidics in a 3D cell culture environment allows the study at the single-cell scale with mechanical

From Organ-on-Chips to Body-on-a-Chip With the help of microfluidics, cell culture is taking the next steps with Organ-on-Chips technology. To highlight these incredible milestones, here we discuss a recent Nature review by Tagle et al.[i], members of the National Center for advancing Translational Sciences; We focus on the benefits of the field, discuss its challenges, and explain