Eden Materials

Flexdym Roll - Microfluidic Product Development

The Flexdym rolls are ideal to boost your device product and more cost-effective than our starter pack. The rolls are available in 3 standard lengths: 20 meters, 35 meters or 90 meters. Each roll is approximately 17 cm wide.  The thickness of the sheet is then available in 4 different thicknesses: 250 µm, 750 µm, 1200 µm and 2000 µm.

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Flexdym Roll™ – Microfluidic Device Development 

Want to boost your microfluidic device development with a scalable and cost-effective alternative to PDMS?

The Flexdym™ is the new biocompatible alternative to PDMS specifically created for the scale up of microfluidic devices and microfluidic device development, in both academia or industry. Flexdym is ideal for biological applications, such as organ-on-chip and point of care diagnostics, because it is certified biocompatible. More specifically, Flexdym™ is certified ISO 10993 (parts 4, 5, 6, 10, 11) and UPS Class VI,  tested for toxicity and can be used for medical applications. Other advantages of Flexdym™ include optical transparency, low molecular sorption properties and reduced gas permeability.

Flexdym is a block co-polymer that combines the best properties of PDMS and thermoplastics. With Flexdym™ device replication is done in minutes and device assembly is a no treatment process. Flexdym™ bonds to a variety of substrates including COC, COP, PS, PC, PMMA, and PDMS. But the bonding strength varies according to the substrate, providing the option between reversible and permanent bonding (see table below). For this reason, Flexdym™ is an excellent option for wearable devices, flexible electronics, or reversible sealing of microfluidic cartridges.

The Flexdym™ rolls are the perfect format for users who need a more cost-effective option after testing our starter pack, but it is also compatible with roll-to-roll embossing methods of mass production. Here, the price per device decreases dramatically, as the roll length increases.

If you are interested in first testing out the Flexdym polymer, check out our Flexdym™ Starter Pack. But if you are interested in Flexdym™ for injection molding mass production or 3D printing, you should see our Flexdym™ Pellets.

And make sure to follow us on Linkedin and watch Flexdym™ tutorials on our youtube channel!

Thickness

250 µm, 750 µm, 1200 µm, 2000 µm

Length

20m, 35m, 90m

Width

17.8 cm

Flexdym Rolls To Boost Your Production Rate

Eden Tech has 3 sizes of Flexdym rolls available to boost your microfluidic chip production. The rolls can be cut and molded using a hot press or they can be used for mass production, via roll-to-roll processes or automated hot embossing. Flexdym rolls are dramatically cheaper compared to the Flexdym starter pack format.

Flexdym Roll Sketch Orange | Eden Tech

The Flexdym rolls are available in 3 lengths: 20 m, 35 m and 90 m. They are wrapped in a protective transparent film.

Flexdym Sheet Thickness orange | Eden Tech

The sheets are avaible in 4 thicknesses: 0.25 mm, 0.75 mm, 1.2 mm, and 2 mm. Cutting the sheets to a desired size is easy.

Flexdym microfluidic device image orangeFlexdym roll orange | Eden Tech

Each sheet can be molded using a hot press or our Sublym machine. Depending on the size of the mold, the process can last from 1 to 15 minutes.

Different Roll Sizes

Flexdym Roll Sketh | Eden Tech

20 metres

Flexdym Roll Sketh | Eden Tech

35 metres

Flexdym Roll Sketh | Eden Tech

90 metres

Step-By-Step:
Flexdym Devices

01

Cut Flexdym Sheet Sketch orange Flexdym microfluidic device image orangeFlexdym roll orange | Eden Tech

Cut a Flexdym sheet

02

Mold Flexdym Sheet Sketch orange | Eden Tech

Mold within 2 minutes

03

Flexdym Create Inlets and Outlets Sketch Orange | Eden Tech

Create inlet/outlet ports

04

Flexdym Device Ready Sketch Orange | Eden Tech

Bond Flexdym to substrate

Flexdym Handling

A Flexdym sheet is protected with films on either side, to avoid contamination of the material by dust particles or other substances. Keep the protective films on the sheet when cutting (using scissors or die cut). Remove the films once you are ready to sandwich your Flexdym sheet between your mold and counter mold. 

Flexdym handling instructionsFlexdym microfluidic device image orangeFlexdym roll orange | Eden Tech

Eden Tech Youtube Channel

Videos & tips demonstrating how easy it is to to use all our products! Find step-by-step explanations on a variety of topics including:

Flexdym Bonding
Flexdym Molding
Flexdym 3D Printing
Sublym for Thermoplastics 
Sublym Program Setup
Epoxym kit steps
and more…

Create Flexdym Microfluidic Devices in Minutes

A Biocompatible Material that is Scalable.

Flexdym at Different scales | Eden Tech

From Prototyping...

Use Flexdym starter packs or rolls to create chips quickly and easily. Mold Flexdym in 2 minutes using our Sublym machine. The Flexdym protocol length is approx. 15-20 minutes, so you can save time in the lab.

To Mass Production.

The Flexdym pellets are compatible with injection molding machines used in mass production. Now you have the opportunity to turn you technology into a commercial product.

Flexdym Pricing

Flexdym’s pricing is comparable to other widely used microfabrication materials, with the added advantages of being:

Biocompatible

Transparent

Scalable

User-Friendly

Gas Permeability Results for Flexdym

PERMEABILITY
FLEXDYM RESULTS
Oxygen
7.86 Barrer
Carbon dioxide
15.99 Barrer
*Results for 2 mm thickness sheet in test conditions 23°C, 50% RH

Resistance to Solvents

CHEMICAL
RESISTANCE
Acids
R
Bases
R
Fluorinated Oils
R
Methanol/ Ethanol
R
Carboxylic Acid
Swell
Hydrocarbons
NR
Oil
Swell

Versatility: Flexdym Bonding Strength

Flexdym combines the best properties of elastomers, like PDMS, and thermoplastics, like COC, polystyrene or polycarbonate. Flexdym acheives this through its block co-polymer structure composed of styrenic hard blocks and ethylene-butylene soft blocks, which allow it to remain soft, yet compatible with hot embossing.

Flexdym acts as a pressure sensitive adhesive, bonding with a selection of substrates through conformal contact. Flexdym bonding can be accomplished through manual lamination using a roller, or standardised through the use of a press.

Flexdym can be recycled and reused. Simply wash or sterilize the molded material (e.g. via gamma treatment) and re-mold.

Finally, Flexdym has tunable bonding strength, which varies according to the material selected as a substrate. 

POLYMER
GRADE
COMPANY
THICKNESS (mm)
Polystyrene (PS)
Crystal Polystyrene
Eloise
1
Polycarbonate (PC)
Lexan *8040
Sabic
0.175
Polyimide (PI)
Kapton HN
Fralock
0.125
Polyimide (PI)
Crilex
Fralock
1
PMMA
Acrylite H12
Eloise
1
COC
Europlex COC 99304
Topas
1
COP
ZenorFilm TM
-
0.1
BONDING STRENGTHS TESTED
Flexdym
8 bars
Glass
700 mbars
COC
2 bars
COP
2 bars
PC
2 bars
PMMA
2 bars
Polyimide
2 bars

POLYSTYRENE (PS)

Strong Bonding, up to several bars.

POLYCARBONATE (PC)

Strong Bonding, up to several bars.

GLASS

Weak Bonding, ranging 500-700 mbar. Best for capillary devices.

POLYDIMETHYLSILOXANE (PDMS)

Weak Bonding.

POLYMETHYLMETACRYLATE (PMMA)

Moderate Bonding.

CYCLIC OLEFIN COPOLYMER (COC)

Strong Bonding, reaching several bars.

CYCLIC OLEFIN POLYMER (COP)

Strong Bonding, reaching several bars.

Top Flexdym Applications Right Now.

Cell Culture

Flexdym has lower sorption properties & gas permeability. 

Reversible Seals

Flexdym can bond reversibly to a variety of substrates, acting as a excellent seal on devices.

Eden Materials Flexdym sheets starter pack alternative to PDMS | Eden Tech

Valves

Flexdym has an elongation of 700%, meaning it can stretch to 7 times is original size.

Skin-Interfacing

Flexdym is a pressure sensitive adhesive that naturally sticks to the skin.

Flexdym Application: Cell Culture

flexdym for cell culture experiements - hugo salmon

1.H. Salmon et al., Engineering Reports 2021, 2. A. McMillian et al., Micromachines 2020

Flexdym has many advantages for bioreactor and cell culture microfluidic applications.

Certified biocompatiblity ISO 10993 parts 4,5,6,10 & 11 and USP Class VI international standards.

Optical transparency, with UV-Vis trasnmittance over 295-800 nm.

Reversible bonding to range of substrates (ideal for switching between open and closed cell culture).

Moderately hydrophobic, but also demonstrates highly stable hydrophilicity with oxygen plasma (1 week to 1 month depending on storage conditions).

Device fabrication in as little as 2 minutes.

Scalable material, also ideal for mass production.

Flexdym Application: Diagnostics

Flexdym also has advantages for microfluidic diagnostic applications.

Low absorption of DNA targets and primers.

Optical transparency, with UV-Vis trasnmittance over 295-800 nm.

Material cost optimization, ideal for diagnostic cartridges.

Resistance to Fluorinated oil for digital amplification.

Thermostability for thermocycling and enzyme activation.

flexdym for point of care diagnostics PCR chip - emmanuel roy

E. Roy et al., Lab on a Chip 2015

Flexdym Mechanical Properties.

Flexdym combines properties of thermoplastics and elastomers. This explains it’s elasticity (Young Modulus of 1.15 MPa) and simultaneous ability to be hot embossed. 

Molding Flexdym:
The Sublym Machine vs. A Hot Press

Eden Tech’s mission is to create user-friendly microfabrication solutions to help researchers boost chip production. With the creation of Flexdym, it was important to offer an affordable machine to mold the material.

Flexdym’s thermoplastic properties means it can be molded via hot embossing, just like other thermoplastics (e.g. COC, polystyrene, or polycarbonate). Hot embossing involves utlizing pressure, heat and  time to transfer features from the mold to the material. Hot embossing is a great alternative to casting and soft-lithgraphy methods of microfabrication.

Explore below 2 methods of hot embossing: 

Sublym hot embossing machine GIF

Sublym100 Machine

1

Optimized for Flexdym molding in only 1-2 minutes!

2

Compact & User-friendly design that requires little to no training.

3

Dramatically cheaper than most standard clean room equipment. This small investment is an opportunity for you to begin exploring microfluidics.

Hotpress CHECK

Classic Hot Press

1

Not optimized for Flexdym molding, therefore longer  molding time.

2

Less easy to use alternative for the Sublym100.

3

Slightly more expensive than the Sublym100, but a standard piece of equipment which is generally installed in fabrication facilities.

Molds For Hot Embossing

Expoxy-resin mold | Eden Tech

Epoxy Resin Mold

Epoxy resin molds are one of the best options for hot embossing. They remain robust through repeated molding cycles. Our Epoxym kit enables the fabrication of epoxy mold replicas from Silicon wafers.

Glass Mold

Glass Mold

Etched glass molds are another robust option for hot embossing. 

 

 

 

Metal Mold

Metal Mold

Metal molds, such as those made from aluminium, are a good option. 

 

 

 

Silicon Wafer

Silicon Wafer

The least ideal option for hot embossing are SU-8 & silicon wafers, due to their fragility and ease of breakage. However, when carefully handled and coated with non-stick spray, they do the trick. 


Flexdym Brochures & Documents

Flexdym is our original and patented material, developed by our CEO Emmanuel Roy. Unlike other materials used in microfluidics device fabrication, Flexdym is the first material created specifically for microfluidics biomedical applications. Our Sublym hot embossing machine was then created to render device replication fast and easy. It is compact, user-friendly and affordable. Finally, our Epoxym kit produces robust mold replicas from silicon wafer molds. For more information on any of these products, check out our brochures below.

    Who are Flexdym Users?

    Flexdym New Material for Academic Microfluidics Prototyping | Eden Tech
    Flexdym New Material for Academic Microfluidics Industrial R&D | Eden Tech
    Flexdym New Material for R&D biotech start-ups | Eden Tech
    Flexdym New Microfabrication material for R&D device fabs | Eden Tech

    What Flexdym Users Say...

    " We are having a great experience using Flexdym sheets to develop our organ-on-chip technology! The protocol is more user-friendly and less messy than what we were used to with PDMS. You skip all the prep work! No mixing or degassing. Eden also provides great customer service throughout the entire process, making it easier for us to advance towards commercializing our devices. "
    CTO Finnadvance Tuan Nguyen
    Tuan Nguyen
    CTO at Finnadvance
    "[...] the Flexdym polymer has become for us an exciting microfluidic medium, allowing us to develop new applications in analytical chemistry as well as cell culture. With original material properties and an excellent capacity for protytping, Eden's materials, instruments and knowledge contributed to develop our autonomy with thermoplastic microfluidics."
    Hugo Salmon Tabrizian group, McGill University
    Hugo Salmon
    McGill University

    Eden Materials Flexdym Clients...

    Flex Users Worldwide

    The Flexdym user community is growing quickly and strongly. Today, Eden Tech has clietns all over the world over 4 different continents. We also have 2 distributors in the United States (Flowcell) and China (Youngchip).

    Eden Tech - Flexdym Users Worldwide

    Scientific Publications

    Flexdym users worldwide are publishing their microfluidics research in top peer reviewed journals including, Nature, Advanced Materials, Analytical Chemistry, Lab on Chip and more. The topics also vary from cell culture and point of care diagnostics, to flexible electronics, wearable devices and micromixers. For a copy of our publications contatc us below!

      Logo Large | Eden Tech

      Eden Tech

      Headquarters:
      11 Rue de Lourmel 
      Paris 75015, France

      Client Facing Offices:
      4 Rue de Rambervillers
      Paris 75012, France

      Trademark Flexdym  and Sublym – EU.IP Offices.

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